ATORVASTATIN

ATORVASTATIN

Chemical Class: Substituted hexahydronaphthalene

Therapeutic Class: HMG-CoA reductase inhibitorl antilipemic

BRAND NAMES	MANUFACTURER	DOSES FORM	GENERIC
Altolip	Webros	Tab 10, 20, 40mg	Atorvastatin
Astatine	Pharmacare	Tab 10mg	Atorvastatin
Astra	Farmaceutics B.G.D	Tab 10, 20mg	Atorvastatin
Atastan	Rehman	Tab 10mg	Atorvastatin
Atopitar	Geonfam pharma	Tab 10, 20, 40mg	Atorvastatin calcium
Atorin	Fynk pharma	Tab 10, 20mg	Atorvastatin
Atorlip	Pearl	Tab 10, 20mg	Atorvastatin
Atorsan	Novartis	Tab 10, 20mg	Atorvastatin
Atorva	Pharmatec	Tab 10, 20, 40mg	Atorvastatin
Atorvastin	Orta labs	Tab 20, 40mg	Atorvastatin
Atorvin	Davis pharma	Tab 10, 20, 40mg	Atorvastatin
Atostat	Donvalley	Tab 20mg	Atorvastatin
Atrachol	Curative	Tab 10, 20mg	Atorvastatin
Atrachol	Hansel	Tab 10, 20mg	Atorvastatin
Atrocal	Panacea pharma	Tab 10, 20mg	Atorvastatin
Atrocard	Himont	Tab 10, 20, 40mg	Atorvastatin
Atrolead	Leqads pharma	Tab 10, 20, 40mg	Atorvastatin
Av	Fozan	Tab 10, 20mg	Atorvastatin
A vast	Wise pharma	Tab 20mg	Atorvastatin
Bvasta	Goodman	Tab 10mg	Atorvastatin
Caliptrol	Ferozsons	Tab 10, 20, 40mg	Atorvastatin
Cal vastatin	Mediate	Tab 10, 20, 40mg	Atorvastatin
Cardistatin	Caylex	Tab 10, 20, 40mg	Atorvastatin
Cholein	Jawa	Tab 10, 20, 40mg	Atorvastatin
Cholestor	PDH	Tab 10, 20, 40mg	Atorvastatin
Colezaf	Zafa	Tab 10, 20mg	Atorvastatin
Colstat	Rasco	Tab 10, 20mg	Atorvastatin
Delip	Standpharm	Tab 10, 20mg	Atorvastatin
Descol	Nabiqasim	Tab 10, 20, 40mg	Atorvastatin
Eravas	Medera	Tab 20mg	Atorvastatin
Etar	English pharma	Tab 10, 20mg	Atorvastatin
Etortin	Amaranth	Tab 10, 20mg	Atorvastatin
Fatilor	Likso	Tab 10, 20, 40mg	Atorvastatin
Fopsec	Merck	Tab 10, 20, 40mg	Atorvastatin
Kolmark	Unimark	Tab 10, 20, 40mg	Atorvastatin
Lastolip	Wilshire	Tab 10, 20, 40mg	Atorvastatin
Lipam	Ambrosia	Tab 10, 20mg	Atorvastatin
Lipica	CSH pharma	Tab 10, 20, 40mg	Atorvastatin
Lipidin	Schazoo	Tab 10, 20, 40mg	Atorvastatin
Lipidip	Beste pharma	Tab 20mg	Atorvastatin
Lipifal	Helix pharma	Tab 10, 20, 40mg	Atorvastatin
Lipiget	Getz pharma	Tab 10, 20, 40mg	Atorvastatin
Lipigam	A.J% co	Tab 10mg	Atorvastatin
Lipirex	Highnoon	Tab 10, 20, 40mg	Atorvastatin
Lipistat	Pulse pharma	Tab 10, 20mg	Atorvastatin
Lipitor	Pfizer	Tab 10, 20, 40mg	Atorvastatin
Lipivastin	Mass pharma	Tab 10, 20, 40mg	Atorvastatin
Lipotrex	Wnsfeild	Tab 20mg	Atorvastatin
Lipotrim	Maple pharm	Tab 10, 20, 40mg	Atorvastatin
Lipvas	Lowitt	Tab 10, 20mg	Atorvastatin
Lochol	Scilife	Tab 10, 20, 40mg	Atorvastatin
Lolipid	Alliance	Tab 10, 20mg	Atorvastatin
Megavastin	Mega	Tab 10, 20mg	Atorvastatin
Ortova	T.G pharm	Tab 10, 20mg	Atorvastatin
Orva	Bosch	Tab 10, 20, 40mg	Atorvastatin
Oscar	Scotmann	Tab 10, 20, 40mg	Atorvastatin
Pro statin	Ccl pharma	Tab 10, 20, 40mg	Atorvastatin
Raytor	Ray pharma	Tab 10, 20, 40mg	Atorvastatin
Reduse	Raazee	Tab 10, 20, 40mg	Atorvastatin
Ridlip	Medicraft	Tab 10, 20mg	Atorvastatin
Rostatin	Stern	Tab 10, 20mg	Atorvastatin
Rostinox	Medipaka	Tab 10, 20mg	Atorvastatin
Rovax	Pharmapek	Tab 10, 20mg	Atorvastatin
Save	Wilson’s	Tab 10, 20, 40mg	Atorvastatin
Sensicon	Barrett	Tab 10, 20, 40mg	Atorvastatin
Snolip	Dynetis	Tab 10, 20mg	Atorvastatin
Stat a	High Q	Tab 10, 20mg	Atorvastatin
Statin	Platinum	Tab 10, 20, 40mg	Atorvastatin
Stator	Tread	Tab 20mg	Atorvastatin
Sunflo	Safe	Tab 10, 20, 40mg	Atorvastatin
Survive at	Werrick	Tab 10, 20, 40mg	Atorvastatin
Tavas	Shaheen	Tab 10, 20mg	Atorvastatin
Tavist	Macter	Tab 10, 20mg	Atorvastatin
Tormed	Medicure	Tab 10, 20, 40mg	Atorvastatin
Torvast	Zanctok	Tab 10, 20, 40mg	Atorvastatin
Trovas	Adamjee	Tab 10, 20mg	Atorvastatin
Univasin	Unison	Tab 20mg	Atorvastatin
Vasclear	Asian continental	Tab 10, 20mg	Atorvastatin
Vaslip	Neutron pharma	Tab 10, 20, 40mg	Atorvastatin
Vastor	Atco	Tab 10, 20mg	Atorvastatin
Vasta	Miracle	Tab 10, 20, 40mg	Atorvastatin
Vozar	Everast	Tab 10, 20, 40mg	Atorvastatin
Winstor	Sanofi Aventis	Tab 10, 20, 40mg	Atorvastatin
Xetrol	Tagma pharm	Tab 10, 20mg	Atorvastatin
Xtor	Drugs inn	Tab 10, 20mg	Atorvastatin
Zepitor	Xenon	Tab 10, 20mg	Atorvastatin
Zumazar	Zumras	Tab 10mg	Atorvastatin

 

INDICATIONS: Primary hypercholesterolemia (heterozygous familial and nonfamilial hypercholesterolemia), mixed dyslipidemia (Fredrickson types Ha and Ilb), hypertriglyceridemia (includes Fredrickson type IV), primary dysbetalipoproteinemia (Fredrickson type III), and homozygous familial hyperlipidemia

CONTRAINDICATIONS: Active liver disease; unexplained persistent elevations of serum transaminases; pregnancy and lactation

DOSE

Adult

Initially 10mg once daily, increased at intervals of 4 weeks to 40mg once daily; if necessary, further increased to max. 80mg once daily

Children

Treatment experience is limited

PRECAUTIONS: Liver dysfunction Pregnancy; not recommended for nursing mothers

SIDE EFFECTS:

CNS: Headache

CV: Migraine, palpitation, postural hypotension, syncope, vasodilation

EENT: Amblyopia, dry eyes, taste disturbances, tinnitus

GI: Abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gastroenteritis, LFT abnormalities

HEME: Anemia, ecchymosis, petechia, thrombocytopenia

METAB: Hyperglycemia, increased creatinine phosphokinase

MS: Arthralgia, leg cramps, myalgia

SKIN: Pruritus, rash

MISC: Face edema, fever, flu-like syndrome, malaise, photosensitivity

INTERACTIONS

Drugs

Azole antifungals (fluconazole, itraconazole, ketoconazole, miconazole): Increased atorvastatin levels; increased risk of rhabdomyolysis

Bile acid sequestrants (cholestyramine, colestipol): 25% reduction in atorvastatin plasma levels if coadministered

Cyclosporine: Concomitant administration increases risk of severe myopathy or rhabdomyolysis Digoxin: Elevation of digoxin level (approximately Erythromycin: Increased atorvastatin concentrations  20%) (approximately 40%); increased risk of rhabdomyolysis Fibric acid: Increased risk of severe myopathy, especially with high statin doses

Nefazodone: Increased atorvastatin levels; increased risk of rhabdomyolysis Niacin: Concomitant administration increases risk of severe myopathy or rhabdomyolysis Oral contraceptives: Coadministration increases AUC for norethindrone and ethinyl estradiol by approximately 30% and 20%, respectively