Enalapril

Rx

• Acelar (Scitech)
Tabs 5mg
Tabs 10mg

• Amotac (Mass Pharma)
Tabs 10mg

• Cardace (Zafa)
  
Tabs 5mg
Tabs 10mg

• Cardil (Himont)
Tabs 5mg
Tabs 10mg

• Cardiotec (Wilson’s)
Tabs 5mg
Tabs 10mg

• Coniuren (Gray’s)
Tabs 5mg
Tabs 10mg

• Cortec (NabiQasim Industries)
Tabs 5mg
Tabs 10mg

• Enalatac (Hygeia)
Tabs 5mg
Tabs 10mg

• Enetec (Alliance)
Tabs 5mg
Tabs 10mg

• Enpril (Bryon Pharma)
Tabs 5mg
Tabs 10mg

• Hipril (Raazee)
Tabs 5mg
Tabs 10mg

• Japril (Jawa)
Tabs 5mg
Tabs 10mg

• Lopritol (Unipharma)
Tabs 5mg

• Maxpril (Makson)
Tabs 5mg
Tabs 10mg

• Napril (Caylex)
Tabs 5mg
Tabs 10mg

• Pril (Regent)
Tabs 5mg
Tabs 10mg

• Redopril (Novartis)
Tabs 10mg

• Renitec (OBS Pakistan)
Tabs 5mg
Tabs 10mg
Tabs 20mg

• Shozupril (Trison)
Tabs 10mg

• Zepres (Asian Continental)
Tabs 5mg
Tabs 10mg

• Zopril (Valor)
Tabs 5mg
Tabs 10mg

Indications:
Hypertension, CHF, MI, erythrocytosis, nephropathy,* retinopathy,* hypralodosteronism,* rheumatoid arthritis*
Contraindications:
Aortric stenosis, hypersensitivity. Pregnancy.
Dose:
Adult
Hypertension: used alone initially 5mg daily; if used in addition to diuretic, in elderly patients, or in renal impairment, initially 2.5mg daily; usual maintenance dose 10-20mg daily; max. 40mg daily. Heart failure: (adjunct) asymptomatic left ventricular dysfunction, initially 2.5mg daily under close medical supervision; usual maintenance 20mg daily in 1-2 divided doses, max; 40mg daily.
Children:
0.1-0.5 (atleast 0.36mg) mg/kg/day as improvised suspension of crushed tablet.
Precautions:
History of anaphylaxis, renal insufficiency (<30 anesthesia="" aortic="" artery="" autoimmune="" b="" breast-feeding:="" caution.="" cirhosis="" collagen="" correctable="" depletion-diuretics="" diabetes="" dialysis="" disease="" diseases="" diuretics="" drug="" elderly="" excessive="" febrile="" fluids="" hyperkalemia="" hypotension="" illness="" immunosuppressant="" min="" ml="" neutropenia="" potassium="" proteinuria="" renal="" sparing="" stenosis="" supplements="" surgery="" therapy="" use="" vascular="" volume="" with="">Old age:

may be used .
Side Effects:
CNS: Anxiety, dizziness, fatigue, headache, insomnia, paresthesia CV: Angina, hypotension, palpitations, postural hypotension, syncope (especially with 1st dose) GI: Abdominal pain, constipation, melena, nausea, vomiting GU: Decreased libido, impotence, increased BUN/creatinine, UTI HEME: Agranulocytosis, neutropenia METAB: Hyperkalemia, hyponatremia MS: Arthralgia, arthritis, myalgia RESP: Asthma, brochitis, cough, dyspnea, sinusitis SKIN: Angioedema, flushing, rash, sweating
Interactions:
Reactions to ACE inhibitors Aspirin, NSAIDs: Inhibition of the antihypertensive Response to ACE inhibitors Azathioprine: Increased myelosuppression Insulin: Enhanced insulin sensitivity Iron: Increased risk of anaphylaxis with administration of parenteral (IV) iron Lithium: Increased risk of serious lithium toxicity Loop diuretics: Initiation of ACE inhibitor therapy in the presence of intensive diuretic therapy results in a precipitous fall in blood pressure in some patients; Ace inhibitors may induce renal insufficiency in the presence of diuretic-induced sodium depletion Potassium: Increased risk of hyperkalemia Potassium-sparing diuretics: Increased risk for hyperkalemia Prazosin, terazosin, doxazosin: Exaggerated first-dose hypotensive response to alpha-blockers Trimethoprim: Additive risk of hyperkalemia, especially in patient predisposed to renal insufficiency
Labs
ACE inhibition can account for approximately 0.5mEq/L rise in serum potassium