ACETAZOLAMIDE (AZM) alternative brands

ACETAZOLAMIDE (AZM)

Chemical Class: Carbonic anhydrase inhibitor; sulfonamide derivative

Therapeutic Class: Anticonvulsant; antiglaucoma agentldiuretic

BRAND NAMES	MANUFACTURER	DOSES FORM	GENERIC
Acemox	Vega	Tab 250mg	Acetazolamide
Azm	Ethical	Tab 250mg	Acetazolamide
Avemox	Donvalley	Tab 250mg	Acetazolamide
Setacar	Remington	Tab 250mg	Acetazolamide

Acetamide

Santé

Tab 250mg

Acetazolamide

INDICATIONS: Open angle glaucoma, narrow-angle glaucoma (preoperatively, if surgery delayed), epilepsy (petit mat, grand mal, mixed), edema in CHF, drug-induced edema, acute mountain sickness (prevention and treatment)

CONTRAINDICATIONS: Pregnancy. Hypersen sitivity to sulfonamides, severe renal disease, severe hepatic disease, electrolyte imbalances (hypo-natremia, hypokalemia), hyperchloremic acidosis, Addison's disease, long-term use in narrow-angle glaucoma

DOSE

Adults

Initially 250-375mg once daily in the morning or on alternate days.

Pre-menstrual oedema: 125-375mg as a single dialy dose beginning 5-10 days before menstruation Epilepsy: Adults: 250-1000mg daily in divided doses.

Children: Under 2 years, 125mg daily; 2-12 years, 125-750mg daily in divided doses.

Glaucoma: Adults: 1-4 daily in divided doses. Children: Infants, 1/2 tab daily; 1/2-3 tabs daily in divided doses. or

Children: 8 to 30mg/kg/day in 3 divided doses. PRECAUTIONS: Hypercalciuria.

Breast-feeding & old age: Use with caution.

SIDE EFFECTS:

CNS: Anxiety, confusion, depression, dizziness, drowsiness, fatigue, headache, nervousness, paresthesia, sedation, seizures, stimulation

EENT: Myopia, tinnitus Gl: Anorexia, constipation, diarrhea, hepatic insufficiency, melena, nausea, taste alterations, vomiting, weight loss

GU: Crystalluria, glucosuria, hypokalemia, polyuria, renal calculi, uremia HEMS: Agranulocytosis, aplastic anemia,

hemolytic anemia, leukopenia, pancytopenia, purpura, thrombocytopenia

METAB: Hyperglycemia

SKIN: Fever, photosensitivity, Stevens-Johnson syndrome, urticaria pruritus, rash,

MISC: Loss of taste of carbonated beverages

INTERACTIONS

Drugs

Cyclosporine: Increased trough cyclosporine levels with potential for neurotoxicity and nephropathy Flecainide, quifzidine: Alkalinization of urine increases duinidine serum levels

Methenamine compounds: Alkalinization of urine decreases antibacterial effects Phenytoin: Increased risk of osteomalacia Primidone: Decreased primidone levels Salicylates: Increased acetazolamideCNS toxicity

Labs

• False increase: 17 hydroxysteroid