FUROSEMIDE (FRUSEMIDE)

FUROSEMIDE (FRUSEMIDE)

Chemical Class: anthranilic acidderivative

Therapeutic Class: antihypertensive; diuretic , loop

BRAND NAMES	MANUFACTURER	DOSES FORM	GENERIC
Aquasin	Siza	Tab 40mg, inj 20mg/2ml	Furosemide
Basix	Xenon	Syp	Furosemide
Elusen	Elite	inj 20mg/2ml	Furosemide
Ephamide	Epharm	Inj 20mg/2ml	Furosemde
Fluromac	Mac & Rains	Sol 40mg/5ml	Furosemide
Frumid	Goodman	Tab 40mg	Furosemide
Frusa	Medera	Tab 40mg	Furosemide
Fruselex	Safa	Tab20, 40mg, inj 20mg/2ml	Furosemide
Fusemid	Akson	Inj 20mg/2ml	Furosemide
Fresmide	Ameer	Inj 20mg/2ml	Furosemide
Frusemide	Nawabsons	Inj 20mg/2ml	Furosemide
Frusinox	Abbott	Tab 40mg	Furosemide
Fymid	Fynk pharma	Tab 40mg	Furosemide
Lasix	Sanofi Aventis	Tab 20,40mg, inj 20mg/2ml	Furosemide
Lawarsemide	Lawrance	Inj 20mg/2ml	Furosemide
Laside	Munawar pharma	Tab 40mg	Furosemide
Losamide	Pharmedic	Tab 40 mg	Furosemide
Odenil	Bosch pharma	Tab 40 mg	Furosemide

 

INDICATIONS:

EDEMA (chF, HEPATIC CIRRHOSIS, renal disease, nephritic syndrome); hypertetnsion, pulmonary edema, hyperclcemia

CONTRAINDICATIONS: Anuria, hepatic coma

DOSE

Adult

By mouth, oedema: Initially 40mg in the morning Adult maintenance 20mg daily or 40mg on alternate days, increased in resistant oedema to 80mg daily. Oliguria: Initially 250mg daily, if necessary larger doses, increasing in steps of 250mg, may be given every 4-6 hours to a max. of a single dose of 2g (rarely used. By i.m. or slow i.v. inj: rate not exceeding 4mg/min. Initially 20-50mg.

By i.v. infusion: (by syringe pump if necessary) In oliguria, initially 250mg over 1 hour (rate not exceeding 4mg/min), if satisfactory urine output not obtained in the subsequent hour further 500mg over 2 hours, then if no satisfactory response within subsequent hour, further 1g over 4 hours, if no response obtained dialysis probably required; effective dose (up to 1g) can be repeated every 24 hours.

 

Children

By mouth: Oedema: 1-3mg/kg daily. By i.m. or slow i.v inj: 0.5-1.5mg/kg to a max. daily dose of 20mg. PRECAUTIONS: Fluid and electrolyte imbalance (including sodium, chloride, potassium, magnesium, calcium), renal disease, hepatic disease (may precipitate hepatic encephalopathy), gout, COPD, lupus erythematosus, diabetes mellitus, hyperparathyroidism, vomiting, diarrhea, elevated cholesterol/triglycerides. PREGNANCY: breast-feeding & old age: Use with caution. 0

 

SIDE EFFECTS:

CNS: Dizziness, fever, headache, paresthesia, restlessness, vertigo

CV: Chest pain, circulatory collapse, ECG changes, orthostatic hypotension

ENT: Blurred vision, ototoxicity

Gl: Anorexia, constipation, cramping, diarrhea, .dry mouth, ischemic hepatitis, jaundice, nausea, oral and gastric irritation, pancreatitis, vomiting

GU: Glycosuria, hyperuricemia, urinary bladder dry oral

HEME: Agranulocytosis, anemia, aplastic anemia, leukopenia, purpura, thrombocytopenia

SKIN: Erythema multiform, exfoliative dermat,interstitial nephritis, necrotizing angiitis, photosensitivity, pruritus, rash, urticaria

 

INDERACTIONS

Drugs

Anticoagulants: Activity of anticoagulants may be enhanced.

Aminoglycoside antibiotics: Furosemide increases potential for ototoxicity.

Cisplatin: Furosemide increases potential for ototoxicity,

Digitalis glycosides: Diuretic-induced potassium loss may precipitate digitalis toxicity, increased frequency of cardiac arrhythmias.

NSAIDS: Effect of furosemide reduced.

Lithium: Therapeutic and toxic effects of lithium

Metolazone: Profound diuresis and greater than predicted electrolyte loss related to the ability of increased. metolazone to block proximal tubular sodium reabsorption useful in patients refractory to Non-depolarising muscle relaxants: Action of succinylcholine and tubocurarine poten-tiated by low furosemide.

doses and reversed by high doses. Food: Efficacy reduced when administered with food.

Propranolol: Plasma propranolol level may be increased.

Clofibrate: Increased diuretic response. Hydantoins: May decrease the diuretic effect.